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jvs 88 BACKGROUND: Abdominal aortic aneurysm AAA represents a significant cause of mortality, yet no medical therapies have proven efficacious. The aim of the current study was to leverage human genetic evidence to inform clinical development of IL-6 interleukin-6 signaling inhibition for the treatment of AAA. METHODS: Associations of rs2228145, a missense variant in the IL6R gene region, are
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