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semaphore a z GABAA receptors GABARs, the main inhibitory neurotransmitter receptors in the mammalian brain, exist in a multitude of subtypes, including forms that predominantly mediate fast inhibitory synaptic transmission and other highly GABA-sensitive extrasynaptic forms that mediate tonic inhibition. GABARs are heteropentameric proteins formed by three different, yet homologous, subunits. Synaptic