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mpo500 Aim of the study This study examined vitexin’s effect on sepsis-induced acute lung injury. We used network pharmacology and in vivo and in vitro experiments were performed to elucidate vitexin’s role in preventing pyroptosis and regulating small nucleolar RNA host gene 1 SNHG1/DNA methyltransferase 1 DNMT1/microRNA-495 miR-495 axis. Materials and methods We developed an acute lung